Faculty Member Profile

Research Interest:
My research interests are on neuroscience, molecular endocrinology, molecular biology, clinical biochemistry and epigenetics to discover novel targets of drugs. I have keen interest for innovation of novel drugs for the treatment of diabetes mellitus, Cushing's disease and to identify novel drugs for other endocrine diseases utilizing my experiences and knowledges of various sensitive techniques- Flow Cytometry, RT-PCR, Electrophoresis, SDS-PAGE, recombinant DNA technology, Luciferase assay and Chromatin Immunoprecipitation assay. I have also interest on environmental biochemistry, nutritional biochemistry and clinical aspects of contagious disease.

Research Articles:
1.    Parvin R, Noro E, Saito-Hakoda A, Shimada H, Suzuki S, Shimizu K, Hiroyuki Miyachi H,Yokoyama A and Sugawara A. Inhibitory Effects of a Novel PPAR-γ Agonist MEKT1 on Pomc Expression/ACTH Secretion in AtT20 Cells," PPAR Research, vol. 2018, Article ID 5346272, 2018. doi:10.1155/2018/5346272.
2.    Parvin R and Sugawara A. “Time and Dose-dependent effects of dexamethasone of Pttg expression in AtT20 Cells," Barisal University Journal Part 1, 5(1):1-13 (2019) ISSN 2411-247X.
3.    Shimada H, Noro E, Suzuki S, Sakamoto J, Sato I, Parvin R, Yokoyama A , Sugawara A. Effects of Adipocyte-derived Factors on the Adrenal Cortex. Curr Mol Pharmacol. 2019 Oct 15. doi: 10.2174/1874467212666191015161334.
4.    4.Noro E, Yokoyama A, Kobayashi M, Shimada H, Suzuki S, Hosokawa M, Tomohiro Takehara T, Parvin R, Shima H, Igarashi K, Sugawara A. Endogenous Purification of NR4A2 (Nurr1) Identified Poly (ADP-Ribose) Polymerase 1 as a Prime Coregulator in Human Adrenocortical H295R Cells. Int. J. Mol. Sci. 2018, 19, 1406; doi:10.3390/ijms19051406.
5.    Parvin R, Saito-Hakoda A, Shimada H, Shimizu K, Noro E, Iwasaki Y, Fujiwara K, Yokoyama A, Sugawara A. Role of NeuroD1 on the negative regulation of Pomc expression by glucocorticoid. PLoS ONE, 12(4): e0175435. April, 2017.
6.    Suzuki D, Saito-Hakoda A, Ito R, Shimizu K, Parvin R, Shimada H, Noro R, Suzuki S, Fujiwara I, Kagechika H, Rainey WE, Kure S, Ito S, Yokoyama A, Sugawara A. Effects of RXR Agonist PA024 on Adrenal CYP11B2 Expression, Aldosterone Secretion and Blood Pressure. PLoS ONE, July, 2017.
7.    Shimada H, Kogure N, Noro E, Kudo M, Sugawara K, Sato I, Shimizu K, Kobayashi M, Suzuki D, Parvin R, Saito-Ito T, Uruno A, Saito-Hakoda A, Rainey WE, Ito S, Yokoyama A, Sugawara A. High glucose stimulates expression of aldosterone synthase (CYP11B2) and secretion of aldosterone in human adrenal cells. FEBS Open Bio, July, 2017.
8.    Parvin R, Saito-Hakoda A, Suzuki S, Noro E, Shimada H, Yokoyama A, Sugawara A. Effects of Retinoids on vasculatures. J Endocrinol Thyroid Res, 2(3): JETR.MS.ID.555587. July, 2017. Review.
9.    Saito-Hakoda A, Uruno A, Yokoyama A, Shimizu K, Parvin R, Kudo M, Saito-Ito T, Sato I, Kogure N, Suzuki D, Shimada H, Yoshikawa T, Fujiwara I, Kagechika H, Iwasaki Y, Kure S, Ito S, Sugawara A. Effects of RXR agonists on cell proliferation/apoptosis and ACTH secretion/Pomc expression. PLoS ONE, 10(12): e0141960. December, 2015.
10.    Uruno A, Saito-Hakoda A, Yokoyama A, Kogure N, Matsuda K, Parvin R, Shimizu K, Sato I, Kudo M, Yoshikawa T, Kagechika H, Iwasaki Y, Ito S, Sugawara A. Retinoic acid receptor-α up-regulates proopiomelanocortin gene expression in AtT20 corticotroph cells. Endocr J, 61(11): 1105-1114. August, 2014.
11.    Saito-Hakoda A, Kogure N, Yoshikawa T, Shimizu K, Iki Y, Sato I, Kudo M, Uruno A, Matsuda K, Parvin R, Sugawara K, Yokoyama A, Ito S, Sugawara A. Is heparan sulfate in the glomerular basement membrane necessary for the etiology of diabetic nephropathy? J Biomol Res Ther, 3: e127. January, 2014.
12.    Ahmed M, Shekhar HU, Parvin R, Nazneen S, Kabir M. Quantitative analysis of hepatitis C virus by real time polymerase chain reaction (qPCR): an assessment of the effect of viral tissue on the severity of liver disease in Bangladeshi patient population. BJMS. 13(2): 127-129. September, 2007.
13.    Parvin R, Uddin MM, Azam MM, Akhteruzzaman S. Prevalence and spectrum of ß-thalassemia and other haemoglobinopathies in a selected population of Bangladesh. BJMS, 12(2): 132-135. September, 2006.

Abstract in Conferences:
International:
1.    Parvin R, Saito-Hakoda A, Shimada H, Noro E, Suzuki S, Miyachi H, Yokoyama A, Sugawara A. Mekt1, A Novel Ppar-gamma Agonist, Significantly Suppressed Pomc Expression/acth Secretion In AtT20 Cells. American Endocrine Society's 99th Annual Meeting and Expo, ENDO 2018, March 17-20 in Chicago.
2.    Parvin R, Sugawara A; Role of NeuroD1 on the Negative Regulation of Pomc Expression by Glucocorticoid, Inhibitory effect of novel PPAR-gamma agonist on Pomc regulation through Nur77/Nurr1 and Tpit in AtT20 cells, 1st Pomc conference in Tokyo, Japan, 2017.09.03.
3.    Parvin R, Saito-Hakoda A, Shimada H, Shimizu K, Yokoyama A, Sugawara A����. Involvement of NeuroD1 on the glucocorticoid-mediated negative regulation of Pomc, 9th retreat conference in Tohoku University, Sendai, Japan. 2016.01.23.
4.    Parvin R, Saito-Hakoda A, Shimada H, Yokoyama A and Sugawara A; Involvement of NeuroD1 on the negative regulation of Pomc expression by dexamethasone, Hypothalamus Pituitary Adrenal axis society meeting, Tokyo, Japan. 2016.03.12.
5.    Parvin R, Saito-Hakoda A, Shimada H, Shimizu K, Noro E, Iwasaki Y, Fujiwara K, Yokoyama A, Sugawara A. Involvement of NeuroD1 on the Negative Regulation of Pomc Expression By Glucocorticoid in AtT20 Cells. Endocrine Society's 98th Annual Meeting and Expo, Boston, April 1—4, 2016.
6.    Parvin R, Saito-Hakoda A, Kyoko Shimizu, Akira Uruno, Dai Suzuki, Satoshi Aoki, Hiroki Shimada, Naotaka Kogure, Masataka Kudo, Yasumasa Iwasaki, Sadayoshi Ito, Atsushi Yokoyama & Akira Sugawara. Examination of the role of NeuroD1 on negative regulation of Pomc expression by Glucocorticoid, Japan Endocrine society meeting, Tokyo, Japan, 2015.04.23.
7.    Parvin R, Akiko Hakoda, Shimizu K, Shimada H, Yokoyama A & Sugawara A;Examination of the role of NeuroD1 on negative regulation of Pomc expression by Glucocorticoid, Tohoku Endocrine society meeting, Sendai, Japan, 2015.05.30.
8.    Kogure N, Matsuda K, Uruno A, Sugawara K, Sato I, Shimizu K, Parvin R, Yoshikawa T, Kudo M, Saito-Hakoda A, Ito R, Yokoyama A, Ito S and Sugawara A. High-Glucose Stimulates Aldosterone Synthase Gene (CYP11B2) Expression Via the Induction of T-Type Calcium Channels in H295R Cells. Endocrine Society's 96th Annual Meeting and Expo, Chicago, June 21—24, 2014.
9.    Saito-Hakoda A, Uruno A, Shimizu K, Kogure N, Parvin R, Sato I, Fujiwara I, Kagechika H, Iwasaki Y, Yokoyama A, Ito S, Sugawara A. Effects of RXR Agonist HX630 on Pomc Promoter Activity and in Vivo Tumor Formation. Endocrine Society's 96th Annual Meeting and Expo, Chicago, June 21—24, 2014.

Educational Attainments:
Ph.D (Doctor of Philosophy)(April, 2014- March, 2017)
Department: Molecular Endocrinology
Institution Name: Tohoku University Graduate School of Medicine, Sendai, Japan.
Dissertation: Role of NeuroD1 on the Negative Regulation of Pomc Expression by Glucocorticoid.
Awarded: On 24th March, 2017

Masters of Science (MS) (Session: 2001-2002)
Department: Biochemistry and Molecular Biology
Institution Name: University of Dhaka, Bangladesh,
Examination held in 2005
Dissertation- Prevalence and Spectrum of Beta-Thalassemia and Other Haemoglobinopathies in a Selected Population of Bangladesh.

Bachelor of Science (BSc-4 yrs Honors) (Session: 2000-2001)
Department: Biochemistry and Molecular Biology
Institution Name: University of Dhaka, Bangladesh
Examination held in 2003

List of Employment:
Designation: Assistant Professor and Chairman,
Organization: University of Barishal, Barishal-8200, Bangladesh
Duration: 1st January, 2018 - till date (2 years 6 months)

Designation: Assistant Professor
Organization: Tohoku University Sendai, Japan
Duration:1st April, 2017 -31st December, 2017 (9 months)

Designation: PhD. Student as a MEXT scholar
Organization: Tohoku University Sendai, Japan
Duration:1st April, 2014-31st March, 2017 (3 years)

Designation: Post Graduate trainee  as a MEXT scholar,
Organization: Tohoku University. Sendai, Japan
Duration:1st October, 2013-31st March, 2014 (6 months)

Designation: Senior Medical Lab. Scientist,
Organization: Square Hospitals Ltd. Dhaka, Bangladesh
Duration:5th August, 2007- 15th September, 2013 (6 years 1 month 10 days)

Designation: Scientific Officer
Organization: Lab Aid Hospitals Ltd. Dhaka, Bangladesh
Duration:1st October, 2005-4th August, 2007 (1 year 10 months 4 days)

Training:

AWARDS and Latest Scholarship:
Research Encouragement Award from Tohoku University, Japan. January, 2016.
-MEXT Scholarship Program, Tohoku University, Japan, Japanese Government, October, 2013-March, 2017 to receive Doctoral degree.

Languages:
Fluent in English and Bengali (Mother tongue) and moderate in Japanese.