Publications
| Sl. | Details |
|---|---|
| 21 | Dr. Rehana Parvin , Effects of Retinoids on Vasculatures Journal of Endocrinology & thyroid Research (JETR) ,3 July, 2017 |
| 22 | Dr. Rehana Parvin , Effects of RXR Agonists on Cell Proliferation/Apoptosis and ACTH Secretion/Pomc Expression PLoS One ,29 December, 2015 |
| 23 | Dr. Rehana Parvin , Effects of RXR Agonist HX630 on Pomc Promoter Activity and in Vivo Tumor Formation ENDOCRINE REVIEWS ,01 June, 2014 |
| 24 | Dr. Rehana Parvin , Generation of a Stable H295R Cell Line Expressing 11beta-Hydroxylase Gene Promoter and the Effect of High-Glucose on Its Expression ENDOCRINE REVIEWS ,01 June, 2014 |
| 25 | Dr. Rehana Parvin , High-Glucose Stimulates Aldosterone Synthase Gene (CYP11B2) Expression Via the Induction of T-Type Calcium Channels in H295R Cells ENDOCRINE REVIEWS ,01 June, 2014 |
| 26 | Dr. Rehana Parvin , Retinoic acid receptor-α up-regulates proopiomelanocortin gene expression in AtT20 corticotroph cells Endocrine journal ,2014 |
| 27 | Dr. Shaila Haque , Phytoremediation: a property of plant to clean up our environment ,31 Aug 2016 Read more |
| 28 | Dr. Shaila Haque , Identification and expression profiling of microRNAs and their corresponding targets related to phytoremediation of heavy metals in jute (Corchorus olitorius var. O-9897) ,1 January 2016 Read more |
| 29 | Dr. Shaila Haque , Interaction of Quercetin of Onion with Axon Guidance Protein Receptor, NRP-1 Plays Important Role in Cancer Treatment: An In Silico Approach Interdisciplinary Sciences: Computational Life Sciences ,26 December 2015 Read more |
| 30 |
BackgroundThe concurrent Zika Virus (ZIKV) outbreaks in the United States and Northeast Brazil have evoked global surveillance. Zika infection has been correlated with severe clinical symptoms, such as microcephaly, Guillain-Barré syndrome, and other congenital brain abnormalities. Recent data suggest that ZIKV predominantly targets neural progenitor cells leading to neurological impairment. Despite the clinical evidence, detailed experimental mechanism of ZIKV neurotropic pathogenesis has not been fully understood yet. Here we hypothesized that ZIKV produces miRNAs, which target essential host genes involved in various cellular pathways facilitating their survival through immune evasion and progression of disease during brain development. MethodsFrom genome sequence information using several bioinformatic tools, we predicted pri-miRNAs, pre-miRNAs, and finally the mature miRNAs produced by ZIKV. We also identified their target genes and performed functional enrichment analysis to identify the biological processes associated with these genes. Finally, we analyzed a publicly available RNA-seq data set to determine the altered expression level of the targeted genes. ResultsFrom ZIKV genome sequence, we identified and validated 47 putative novel miRNAs. Functional enrichment of the targeted genes demonstrates the involvement of various biological pathways regulating cellular signaling, neurological functions, cancer, and fetal development. The expression analysis of these genes showed that ZIKV-produced miRNAs downregulate the key genes involved in these pathways, which in turn may lead to impaired brain development. ConclusionsOur finding proposes novel ZIKV miRNAs and their targets, which upon experimental validation could help developing new therapeutics to combat ZIKV infection and minimize ZIKV-mediated pathologies. |