Faculty Member Profile

RESEARCH EXPERIENCES

[1] DPhil Research

Chemistry Research Laboratory, University of Oxford, Oxford, United Kingdom

Title: Methodology for the Conversion of Tetramates to Pyroglutamates, and A Study of their Biological Activities

DPhil research includes:

• Development of a methodology for the Conversion of Tetramates to Pyroglutamates

• Synthesis of a library of Pyroglutamate derivatives

• Functionalization of Tetramates

• N,O-Acetal deprotection, Suzuki coupling, Hydrogenation, Dieckmann cyclization, Preparation of Sulfone and Sulfoxide analogues

• Separation of compounds by flash column chromatography

• Crystal formation for X-ray crystallography

• Experimental technique: LRMS, HRMS, 1H-NMR, 13C-NMR, IR

• Analysis: LRMS, HRMS, 1H-NMR, 13C-NMR, COSY, HSQC, DEPT, IR, X-ray crystallography data, NOE correlations etc.

• Antibacterial screening

[2] MS (Thesis) Research

Jahangirnagar University, Dhaka, Bangladesh

Title: Synthesis of Some Mannich Bases of Isatin Derivatives and their Schiff Bases as Probes for Pharmacological Studies.

MS (Thesis) includes:

• Synthesis of Mannich and Schiff bases and their derivatives

• Synthesis of 3'H-spiro[indoline-3,2'-[1,3,4]thiadiazole] derivatives

• Separation of compounds by column chromatography

• Analysis of the synthetic variants MS, 1H-NMR, 13C-NMR, IR data

• Measurement of cytotoxic activity expressed in LD50 values

[3] Industrial Training

Institute of Glass & Ceramic Research and Testing (IGCRT), Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh

Title: Physical and Chemical Analysis of Ordinary Portland Cement

PUBLICATIONS

1. “Synthesis and Characterisation of a Series of Mannich Bases as Cytotoxic Agents”, H. Bagum, M. A. Hossain, M. Al-Amin, and M. R. Islam, Journal of Bangladesh Chemical Society, 2013, 26(1), 93.

2. "Synthesis of Some Mannich and Schiff Bases from Isatin and their Cyclization Products", H. Bagum, and M. R. Islam, Journal of Bangladesh Chemical Society, 2014, 27(1).

3. "Synthetic Access to 3-Substituted Pyroglutamic Acids from Tetramate Derivatives of Serine, Threonine, allo-Threonine, and Cysteine", H. Bagum, K. E. Christensen, M. Genov, A. Pretsch, D. Pretsch, and M. G. Moloney, The Journal of organic chemistry, 2019, 84(16), 10257-10279.

4. "Synthetic access to 3, 4-disubstituted pyroglutamates from tetramate derivatives from serine, allo-threonine and cysteine", H. Bagum, K. E. Christensen, M. Genov, A. Pretsch, D. Pretsch, and M. G. Moloney, Tetrahedron, 2019, 75(40), 130561.

5. "Bicyclic Lactams Derived from Serine or Cysteine and 2-Methylpropanal", H. Bagum, B. R. Shire, K. E. Christensen, M. Genov, A. Pretsch, D. Pretsch, and M. G. Moloney, Synlett, 2020, 31(04), 378-382.

ACADEMIC HONORS

[1]          Jahangirnagar University Entrance Scholarship || 2006

[2]          Merit Scholarship, Jahangirnagar University || 2007, 2008, 2009, 2010

[3]          University Grand Scholarship (UGC) for outstanding results in the B.Sc. (Honors) examination || 2009

[4]          National Science, Information and Communication Technology Fellowship for research activities in MS (Thesis) || 2011

[5]          Commonwealth Scholarship to read for DPhil in Organic Chemistry at University of Oxford || 2015

CONFERENCES AND SESSIONS
 
[1]          XXII International Conference on Organic Synthesis – 22-ICOS (2018), Direct Conversion of Tetramates to Pyroglutamates

[2]          17th Bristol Synthesis Meeting 2017

[3]          Bristol Synthesis Meeting 2018

[4]          Oxford Synthesis Summer Conference 2018

[5]          Organic Chemistry Colloquium || 2016, 2017, 2018

[6]          The Robert Robinson Lectures 2018

COURSES

[1]          English for Academic Studies (EAS) course at Oxford University Language Center: This course includes key issues, a series of workshops, writing a thesis, preparing corpora for academic writing, writing in my field using corpora, etc. I find this course useful to improve academic writing.

[2]          Research Integrity: Through lecture, discussion, and case studies this training helps to develop an understanding of research integrity issues – both in principle and in practice in participants’ research contexts.

[3]          UAS skill course- Poster Design and Presentation.

[4]          How to be More Effective in Your Postgraduate Research: Overcoming the Psychological Challenges.

[5]          Academic Literacy Study Skills Session || 2018